AEMCA Practice Exam

What does hyperthermia in serotonin syndrome typically result from?

1. Overactivity of the heart

2. Excessive sweating

3. Overactive muscle contraction

4. Low blood pressure

The correct answer is: Overactive muscle contraction

Hyperthermia in serotonin syndrome is primarily associated with overactive muscle contraction, which is a hallmark of this condition. Serotonin syndrome occurs when there is an excess of serotonin in the central nervous system, often triggered by certain medications or drug interactions. This excess leads to increased neuromuscular activity, which can result in muscle rigidity, clonus, or other involuntary muscle contractions. As the muscles contract excessively, they generate heat, contributing to an increase in body temperature, or hyperthermia. This thermoregulatory impairment is a critical factor in the syndrome and can lead to serious complications if not addressed promptly. While overactivity of the heart, excessive sweating, and low blood pressure may occur in the context of serotonin syndrome, they are not the primary drivers of hyperthermia. Elevated heart rate and sweating can result from sympathetic nervous system activation but are secondary effects rather than direct causes of the hyperthermic state associated with muscle overactivity.