AEMCA Practice Exam

What primarily causes the inflammation in type 2 intrinsic asthma?

1. Seasonal allergens

2. Long-term exposure to irritants

3. Sudden exposure to cold air

4. Genetic predisposition

The correct answer is: Long-term exposure to irritants

The primary cause of inflammation in type 2 intrinsic asthma is long-term exposure to irritants. This form of asthma is characterized by chronic inflammation of the airways, which can be triggered by various environmental factors. In contrast to type 1 asthma, often caused by specific allergens, type 2 intrinsic asthma is commonly linked to irritants such as tobacco smoke, air pollution, or other pollutants that a person might encounter over an extended period. Long-term exposure to these irritants leads to ongoing inflammatory processes in the airways, significantly impacting the immune response and eventually resulting in asthma symptoms. This chronic irritation can cause the airways to become hyperresponsive, leading to difficulties in breathing, wheezing, and other asthma-related issues. While seasonal allergens, sudden exposure to cold air, and genetic predisposition can influence asthma, they do not primarily trigger the inflammation seen in type 2 intrinsic asthma as significantly as long-term irritant exposure does.