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Which of the following is NOT a symptom of Cushing's syndrome?

  1. Obese trunk

  2. Moon-shaped face

  3. Hyperactivity

  4. Purple striations on the trunk

The correct answer is: Hyperactivity

Cushing's syndrome is characterized by an overproduction of cortisol, which leads to a variety of physical and psychological symptoms. The condition often results in distinct physical traits and health issues. When evaluating the symptoms associated with Cushing's syndrome, symptoms like an obese trunk, a moon-shaped face, and purple striations on the trunk commonly manifest. An obese trunk refers to the concentration of fat in the torso area, leading to a characteristic appearance that patients often exhibit. The moon-shaped face describes the rounded visage commonly seen in individuals with this syndrome due to fat deposition. Likewise, purple striations or stretch marks on the trunk are a direct consequence of skin changes related to excess cortisol levels. On the other hand, hyperactivity is not typically associated with Cushing’s syndrome. In fact, the syndrome often leads to emotional disturbances such as depression, anxiety, or fatigue rather than hyperactivity. This distinction is crucial, as recognizing the psychological symptoms of Cushing's can help in understanding the broader impact of the syndrome on patients' lives. Therefore, the correct identification of hyperactivity as not being a symptom of Cushing's syndrome aligns well with the established clinical understanding of the disorder.