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Which of the following symptoms might indicate an opioid overdose?

  1. Rapid heartbeat and elevated blood pressure

  2. Pinpoint pupils and respiratory depression

  3. Excessive sweating and tremors

  4. Increased sensitivity to pain

The correct answer is: Pinpoint pupils and respiratory depression

Opioid overdose can lead to specific physiological symptoms that are crucial for recognition and intervention. Pinpoint pupils, a common sign of opioid intoxication, indicate a constriction of the pupils as a result of increased opioid activity in the central nervous system. Respiratory depression is particularly critical in overdose situations since opioids can suppress the respiratory centers in the brain, leading to inadequate breathing and potentially life-threatening situations. Together, these symptoms are classic indicators of an opioid overdose and warrant immediate medical attention. Other symptom choices may be indicative of different conditions or reactions, but they do not represent the hallmark signs of an opioid overdose. Rapid heartbeat and elevated blood pressure might occur in various stress or withdrawal scenarios, whereas excessive sweating and tremors could be symptoms of withdrawal or anxiety rather than overdose. Increased sensitivity to pain is more related to the physiological effects of opioid use rather than an overdose scenario. Thus, pinpoint pupils and respiratory depression stand out as definitive signs that demand urgent response in the context of potential opioid overdose.